Penn State Science
Andrew F. Read

Andrew F. Read

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Professor of biology and entomology and Alumni Professor in Biological Sciences

W-230A Millennium Science Complex
University Park, PA 16801
Phone: (814) 867-2396
Lab Address: W-124 MSC
Lab Phone: (814) 867-2397

Education:

  1. Ph.D., University of Oxford, 1989
  2. B.S., University of Otago, New Zealand, 1984

Honors and Awards:

  1. Fellow of American Association for the Advancement of Science (elected 2012)
  2. Fellowship Wissenschaftskolleg zu Berlin, 2006-2007
  3. Fellow of Royal Society of Edinburgh (elected 2003)
  4. Scientific Medal, Zoological Society of London, 1999
  5. Young Investigator Award, American Society of Naturalists, 1991
  6. Thomas Henry Huxley Award, Zoological Society of London, 1991

Research Interests:

We work on the ecology and evolution of infectious disease. We exploit modern notions of adaptive evolution to attack biomedically and theoretically challenging phenomena like virulence and infectiousness, adaptation to new hosts, vaccine escape, and drug and insecticide resistance. Our work involves evolutionary biology, ecology, parasitology, microbiology, genetics, and immunology. Currently, much of the work concerns the three players that cause malaria (the parasite, the vertebrate host, and the mosquito), as well entomopathogenic fungi and Marek’s disease of chickens. In the past, we also have worked on the parasites of Daphnia, African trypanosomes, and parasitic nematodes of mammals.

Selected Publications:

Read, A. F., T. Day, and S. Huijben. 2011. The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy. Proceedings of the National Academy of Sciences USA June 20. doi: 10.1073/pnas.1100299108.

Read, A. F., P. A. Lynch, and M. B. Thomas. 2009. How to build an evolution-proof insecticide for malaria control. PLoS Biology 7(4): e1000058.

Wargo, A. R., S. Huijben, J. C. de Roode, J. Shepherd, and A. F. Read. 2007. Competitive release and facilitation of drug resistant parasites following therapeutic chemotherapy in a rodent malaria model. Proceedings of the National Academy of Sciences USA 104: 19914.

Råberg, L., D. Sim, and A. F. Read. 2007. Disentangling genetic variation for resistance and tolerance to infectious diseases in animals. Science 318: 812.

Blanford, S., B. H. Chan, N. Jenkins, D. Sim, R. J. Turner, A. F. Read, M. B. Thomas. 2005. Fungal pathogen reduces potential for malaria transmission. Science. 308: 1638.

de Roode, J. C., R. Pansini, S. J. Cheesman, M. E. H. Helinski, S. Huijben, A. R. Wargo, A. S. Bell, B. H. K. Chan, D. Walliker, and A. F. Read. 2005. Virulence and competitive ability in genetically diverse malaria infections. Proceedings of the National Academy of Sciences USA 102: 7624.

Mackinnon, M. J. and A. F. Read 2004. Immunity promotes virulence evolution in a malaria model. PLoS Biology. 2(9): e230.

Gandon, S., M. J. Mackinnon, S. Nee, and A. F. Read. 2001. Imperfect vaccines and the evolution of pathogen virulence. Nature. 414: 751.

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