Edward C Holmes
Professor of Biology and Eberly College of Science Distinguished Senior Scholar
608 MuellerEducation:
- Ph.D, University of Cambridge, UK. (1990).
- B.Sc, University of London (University College), UK. (1986).
Postdoc Training:
- University of Oxford, United Kingdom, 1993-1994
- University of Edinburgh, United Kingdom, 1991-1993
- University of California, Davis, 1990-1991
Honors and Awards:
- • 2011: Australia Fellow, National Health and Medical Research Council (NHMRC).
- • 2010: Fogarty International Center Director’s Merit Award to the Multinational Influenza Seasonal Mortality Study Team (MISMS).
- • 2010: Faculty Scholars Medal in the Life and Health Sciences, The Pennsylvania State University.
- • 2008: Kavli Fellow, National Academy of Sciences, USA.
- • 2003: Scientific Medal for achievement in research by a zoologist under the age of 40. Zoological Society of London.
Research Interests:
I am an evolutionary biologist who has worked with viruses for over 20 years. My research has focused on a number of key areas, namely (i) determining the fundamental mechanisms of viral evolution, (ii) studying the case-specific evolution of major viral infections of humans and animals, with a particular focus on influenza and dengue, (iii) revealing the evolutionary genetics of viral emergence, and (iv) assisting in the development of bioinformatic methods for gene/genome sequence analysis. My current research sits at the interface of four disciplines—evolutionary biology, genomics, bioinformatics, and infectious disease—and is designed to reveal the factors that are responsible for the successful cross-species transmission of viral pathogens into humans and other eukaryotic species.
Selected Publications:
Lam TT-Y, Ip HS, Ghedin E, Wentworth DE, Halpin RA, Stockwell TB, Spiro DJ, Dusek RJ, Bortner JB, Bales BD, Yparraguirre DR & Holmes EC.. (2012). Migratory flyway and geographical distance are barriers to the gene flow of influenza virus among North American birds. Ecol.Lett. 15, 24-33.
Holmes, E. C. 2011. What does virus evolution tell us about virus origins? J. Virol. 85: 5247-5251.
Kitchen, A., L. Shackelton, and E. C. Holmes. 2011. Family level phylogenies reveal modes of macroevolution in RNA viruses. Proc. Natl. Acad. Sci. USA 108: 238-243.
Holmes, E. C. 2010. The comparative genomics of viral emergence. Proc. Natl. Acad. Sci. USA. 107: 1742-1746.
Holmes, E.C. 2009. The Evolution and Emergence of RNA Viruses. Oxford Series in Ecology and Evolution (OSEE). Series edited by P. H. Harvey and R. M. May. Oxford University Press, Oxford.
Holmes, E. C. 2009. The evolutionary genetics of emerging viruses. Annu. Rev. Ecol. Evol. Syst. 40: 353-372.
Holmes, E. C. and B. T. Grenfell. 2009. Discovering the phylodynamics of RNA viruses. PLoS Comput. Biol. 5: e1000505.
Duffy, S., L. A. Shackelton, and E. C. Holmes. 2008. Rates of evolutionary change in viruses: Patterns and determinants. Nat. Rev. Genet. 9: 267-276.
Holmes, E. C. 2008. The evolutionary history and phylogeography of human viruses. Annu. Rev. Microbiol. 62: 307-328.
Nelson, M. I., L. Edelman, D. J. Spiro, A. R. Boyne, J. Bera, R. Halpin, E. Ghedin, M. A. Miller, L. Simonsen, C. Viboud, and E. C. Holmes. 2008. Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States. PLoS Pathog. 4: e1000133.
Rambaut, A., O. G. Pybus, M. I. Nelson, C. Viboud, J. K. Taubenberger, and E. C. Holmes. 2008. The genomic and epidemiological dynamics of human influenza A virus. Nature 453: 615-619.
Page, R. D. M. and E. C Holmes. 1998. Molecular Evolution: A Phylogenetic Approach. Blackwell Science Ltd, Oxford.
(from a total of 313 peer-reviewed publications; ~17,500 citations; h-index = 68)
