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Center for Gene Regulation

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Gene regulation lies at the heart of most biological processes. Developmental and evolutionary biology, the mechanisms of cell growth and differentiation, and their abrogation in devastating conditions such as cancer and human genetic diseases - all are concerned intimately with the regulation of genes. The goal of Penn State's Center for Gene Regulation is to foster collaborative, interdisciplinary research into the fundamental processes of gene regulation and their impact on cellular and developmental biology. Current activities include organizing symposia, building core facilities such as the phosphorimager/image analysis facility, and helping to recruit new faculty into represented departments (Biology, Biochemistry and Molecular Biology, Veterinary Science, Horticulture, and Computer Science and Engineering).

Research thrusts include muscle development in fruit flies, gene regulation in yeast, gene regulation by plant hormones, molecular approaches to pathogenicity and tumorgenicity in animal viruses, transcription potential of heat shock genes in fruit flies, hormonal control of plant gene expression, control of globin genes in mammals, molecular basis of self-incompatibility in plants, genetic engineering of plant development, software for sequence analysis, sensory transduction and transcriptional regulation in bacteria, biochemistry of transcription initiation, molecular genetics of xenobiotic metabolism, molecular and cell biology of red blood cells, and chromatin and gene expression.