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"Systematic analysis of noncoding genetic variants"

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Kai Tan Associate Professor, The Children's Hospital of Philadelphia & Perelman School of Medicine at the University of Pennsylvania
15 October 2019 from 3:30 PM to 4:30 PM
8 Mueller Lab
Dept of Biology
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Systematic Analysis of Noncoding Genetic Variants

Kai Tan

The vast majority of genetic variants in the human genome are located in the noncoding region. Functional interpretation of causal noncoding variants has remained a major challenge in human genetics. In this talk, I will present a couple of computational algorithms for predicting causal noncoding variants by integrating large scale omics datasets. I will also present a couple of case studies on identifying and validating germline variants in type 1 diabetes and somatic variants in pediatric cancers. Our work established a much-needed systemic approach to identifying and characterizing noncoding causal variants in human diseases.