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BIOL 133

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Biology 133: GENETICS AND EVOLUTION OF THE HUMAN SPECIES

Spring 2015

2:30-3:20 MWF, 112 Buckhout

Instructor:   Denise Woodward, Email through ANGEL (messages sent through regular email will not be answered), 865-9363 (for emergencies only)

Office Hour:  Wednesdays, 1:00-2:00 – 329 Whitmore

Teaching Assistant:  Satbyol Kang, Email through ANGEL

Office Hours: TBA

Objectives

This course is an overview of our current knowledge of human genetics and genetic issues, with special attention to issues that are relevant to non-scientists.  We will cover background information that is necessary for understanding these issues, including the structure and function of DNA, chromosomes, inheritance, population genetics, cancer, and genetic technology.  This course will include multimedia presentations, textbook readings, classroom activities and problem-solving.  The goal of this course is to provide students with sufficient scientific knowledge to make informed decisions about genetic issues and the ability to discuss these issues intelligently.

Course Format

This course will incorporate lectures, videos, and in-class activities.  You are expected to have done the readings prior to class so you can participate in these activities.    

Course Materials

Textbook:  Lewis, R. 2012.  Human Genetics, Concepts and Applications.  10th Edition. McGraw-Hill Publishers. 

iClicker:  We will be using the i>clicker remote for in-class participation.  i>clicker is a response system that allows you to respond to questions posed during class, and your responses will be graded.  In order to receive credit, you will need to register your i>clicker remote online using the link in ANGEL.  Your student ID should be your Access Account ID, i.e., the user name that forms the first part of your Penn State email address and that you would use to login to ANGEL. DO NOT enter in your 9-digit student number. The remote ID is the series of numbers and sometimes letters found on the bottom of the back of your i>clicker remote. i>clicker will be used most day in class, and you are responsible for bringing your remote daily.

Online Course Materials: All course materials can be accessed through ANGEL (you will need your Penn State access account username and password).  You will find the syllabus, PowerPoint outlines, movie questions and additional information on ANGEL.  

Grading

All exams and assignments are worth 600 points.  No extra credit will be offered.  Final grade assignments will be determined based on the score distribution of the class.  If you are concerned about your grade, contact the instructor or TA early in the semester, and not during the last week of class.

Exams

There will be 4 exams during the semester.  Each exam is worth 120 points. You will be responsible for all material presented during class time (including movies and practice problems).  Material presented in the textbook but not covered in class will not be on the exams.  Exams are not cumulative. 

The exams will be taken in the e-Testing center in Pollock Building.  Please watch the video on that web page to know what to expect when you take your exam.  You must have your student ID with you to enter the testing facility.  You must schedule your exam in advance through the e-Testing website – there is a link on the page titled information for students.  It is your responsibility to schedule your exam and to be present at the testing facility well before your scheduled time (there may be a line).  If you begin the exam late, you will only have through the end of your scheduled time to complete it.  If you forget to sign up for a time, you will receive a zero for that exam.  

Attendance at exams is mandatory; if you miss your scheduled time you must contact the course coordinator within 24 hours of missing the exam.  All makeup exams must be completed within 5 business days of the normally scheduled exam.  The following are the only legitimate excuses for missing an exam:

Illness 

A University sponsored event (with note from sponsor) 

Religious holiday recognized by PSU 

Death in the family (you must provide documentation with a date)

To view your exam results, you must attend an office hour (or make an appointment). 

Clicker Questions

Most class days will include graded clicker questions.  Each graded question is worth 1 point when answered correctly (there may also be ungraded questions).  You can earn a maximum of 20 points from these questions (5 points per exam block).  There are no make ups for clicker questions – you must be in class to receive these points and you must register your clicker online and have your clicker with you during each class.  To receive credit for your clicker questions, you must have your Penn State username (e.g., abc123) entered as your clicker ID.  There will be more questions asked than can be earned credit for – each student can miss several classes per exam block and still earn full clicker points.

Writing Assignments

There will be two written assignments.  They are due in the drop box on ANGEL by the start of class on the date listed on the syllabus.  It is your responsibility to make sure your assignments have been submitted to the drop box properly (see assignment for details about how to submit).  Each assignment is worth 25 points.  Late assignments will have points deducted (20% of the total grade per day for two days, after two days the assignment will not be accepted).

ANGEL Quizzes

There will be 4 ANGEL quizzes (one per exam block) and each quiz is worth 12.5 points (for a total of 50 points).   Each quiz will be open for one week and must be completed by the date indicated on the class schedule.  Each quiz will consist of ~15 questions and you will have 35 minutes to complete the quiz.  DO NOT OPEN THE QUIZ UNTIL YOU ARE READY TO TAKE IT. There are no makeups for the quizzes.    

Academic Integrity/Academic Dishonesty  

Academic dishonesty is not limited to simply cheating on an exam or assignment.  The following is quoted directly from the "PSU Faculty Senate Policies for Students" regarding academic integrity and academic dishonesty:  “Academic integrity is the pursuit of scholarly activity free from fraud and deception and is an educational objective of this institution.  Academic dishonesty includes, but is not limited to, cheating, plagiarizing, fabricating of information or citations, facilitating acts of academic dishonesty by others, having unauthorized possession of examinations, submitting work of another person or work previously used without informing the instructor, or tampering with the academic work of other students.”

All University and Departmental policies regarding academic integrity/academic dishonesty apply to this course and the students enrolled in this course.  Refer to the following URL for further details on the academic integrity policies of the Department of Biology  

Each student in this course is expected to work entirely on her/his own while taking any exam, to complete assignments on her/his own effort without the assistance of others unless directed otherwise by the instructor, and to abide by University and Department of Biology policies about academic integrity and academic dishonesty.  Academic dishonesty can result in assignment of “F” by the course instructors or "XF" by Judicial Affairs as the final grade for the student.

Disabilities  

Penn State encourages qualified persons with disabilities to participate in its programs and activities.  If you anticipate needing any type of accommodation in this course or have questions about physical access, please contact the instructor or the Penn State Office for Disability Services.

Assignment of Grades

The grading scale (based on 600 total points for the course) is: 
 
A 558-600 points       C+ 450-479 points
A- 540-557 points     C 420-449 points
B+ 522-539 points    D 360-419 points
B 498-521 points       F Fewer than 359 points  
B- 480-497 points                                            
                                

Day

Date

Schedule of Topics

 

Reading Assignment

M

1/12

Introduction to Course/ Overview of Syllabus

 

W

1/14

Introduction to Human Genetics

Chapter 1

F

1/16

Cells

Chapter 2

M

1/19

No Class – Martin Luther King, Jr. Day

 

 

W

1/21

Cells – continued

Chapter 2

F

1/23

Meiosis and Development

Chapter 3 (pg 46–62)

M

1/26

Video:  Life’s Greatest Miracle

 

Questions – ANGEL (you do not hand these in but there will be clicker and exam questions)

W

1/28

Genetic Analysis I – Mendel & Genetic Vocabulary

Chapter 4

F

1/30

Genetic Analysis II – Dihybrid crosses and Pedigree Analysis

Chapter 4

M

2/02

Exceptions to Mendel’s Laws I

ANGEL Quiz #1 due at 11:00PM today (covers Chapters 1-3)

Chapter 5

W

2/04

Exceptions to Mendel’s Laws II

Chapter 5

F

2/06

Sex Differences and Inheritance

Chapter 6

M

2/09

Sex Differences and Inheritance – continued

Chapter 6

W

2/11

The Royal Family and Hemophilia Case Study

 

R-F

2/12-2/13

Exam 1:  Chapters 1-6, The Royal Family and Hemophilia, and Video – e-Testing center.  The exam will be offered from 8 am – 11 pm – you must sign up in advance for an exam time

M

2/16

Video: Cracking your Genetic Code

Questions – ANGEL

W

2/18

Multifactorial  Traits

Chapter 7

F

2/20

The Genetics of Human Behavior

Chapter 8

M

2/23

DNA Structure and Replication

Chapter 9

W

2/25

Gene Action

ANGEL Quiz #2 due at 11:00PM today (covers Chapters 7-9)

Chapter 10

F

2/27

Gene Action

Chapter 10

M

3/02

Gene Expression and Epigenetics I

Chapter 11

W

3/04

Gene Expression and Epigenetics II

Chapter 11

R-F

3/05-3/06

Exam 2: Chapters 7-11, Forensics and Genetics, and Video – e-Testing center.  The exam will be offered from 8 am – 11 pm – you must sign up in advance for an exam time

3/9-3/15

Spring Break – Have fun!

 

M

3/16

Gene Mutations

Chapter 12

W

3/18

Chromosomes

Chapter 13

F

3/20

Library Day #1  (no class) – use this time to complete writing assignment #1

M

3/23

Population Genetics I /

Writing Assignment #1 due

Chapter 14

W

3/25

Population Genetics II

Chapter 15

F

3/27

Video: Forensics on Trial

Questions – ANGEL

M

3/30

Population Genetics and Forensics Case Study

ANGEL Quiz #3 due at 11:00PM today (covers Chapters 12-15)

 

W

4/01

Human Evolution

Chapter 16

F

4/03

Video:  What Makes Us Human?

Questions – ANGEL

M

4/06

Genetics and Immunity

Chapter 17

W

4/08

Genetics and Cancer

Chapter 18

R-F

4/09-4/10

Exam 3: Chapters 12-18, Population genetics examples, and Video – e-Testing center.  The exam will be offered from 8 am – 11 pm – you must sign up in advance for an exam time

M

4/13

Library Day #2 (no class) – use this time to complete writing assignment #2

W

4/15

Video: The Ghost in Your Genes /

Writing Assignment #2 due

Questions – ANGEL

F

4/17

Genetic Engineering and GMOs

Chapter 19

M

4/20

Gene Testing and Genetic Counseling

Chapter 20

W

4/22

Reproductive Technologies I

ANGEL Quiz #4 due at 11:00PM today (covers Chapters 17-20)

Chapter 21

F

4/24

Reproductive Technologies II

Chapter 21

M

4/27

Selecting the Perfect Baby Case Study

 

W

4/29

Genomics

Chapter 22

R-F

4/30-5/01

Exam 4: Chapters 19-22, Selecting the Perfect Baby, and Video – e-Testing center.  The exam will be offered from 8 am – 11 pm – you must sign up in advance for an exam time