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BIOL 432 
DEVELOPMENTAL GENETICS
Last revised: September 10, 2013

 

 

Instructor:

Dr. Aimin Liu

104C Life Sciences Building

814-865-7043

axl25@psu.edu

Office Hours:  by appointment

 

Brief Description:

An advanced course in developmental biology, focusing on the use of genetics techniques to study fundamental questions of animal development. Prerequisite: BIOL 230W ; or B M B 251 , B M B 252 

 

Course Materials:

Textbook: No textbook is required. Some material from the following three books will be used, but students are not required to buy them. 

1. Developmental Biology, 7th edition , by Gilbert

2. Campbell Biology, 9th edition, by Reese et al

3. Genetics: Analysis of Genes and Genomes, 8th edition, by Hartl

 

Required Reading:  During the semester, we will read, present and discuss research papers as a class.  A list of these papers will be provided and the papers posted on-line. Powerpoint presentations for each lecture will also be posted and students are strongly encouraged to go through them before and after the lecture. 


On-line course materials: ANGEL (https://cms.psu.edu)

 

Academic Integrity/Academic Dishonesty:

Academic dishonesty is not limited to simply cheating on an exam or assignment.  The following is quoted directly from the “PSU Faculty Senate Policies for Students” regarding academic integrity and academic dishonesty; “Academic integrity is the pursuit of scholarly activity free from fraud and deception and is an educational objective of this institution.  Academic dishonesty includes, but is not limited to cheating, plagiarizing, fabricating of information or citations, facilitating acts of academic dishonesty by others, having unauthorized possession of examinations, submitting work of another person or work previously used without informing the instructor, or tampering with the academic work of other students.”  Lying to gain an advantage over other students is also an academic integrity violation.

All University and Departmental policies regarding academic integrity/academic dishonesty apply to this course and the students enrolled in this course.  Refer to further details on academic integrity policies of the Eberly College of Science (http://www.science.psu.edu/academic/Integrity/Policy.htm.)  Each student in this course is expected to work entirely on his/her own while taking any exam, to complete assignments on his/her own effort without the assistance of others unless directed otherwise by the instructor or teaching assistant, and to abide by University and College policies on academic integrity and academic dishonesty.  Academic dishonesty either in lab or lecture can result in an assignment of “F” by the course instructors or “XF” by Judicial Affairs as the final grade for the student.  Students are responsible for ensuring that their work is consistent with Penn State’s expectations about academic integrity. 

 

Students with Disabilities. 

Penn State welcomes students with disabilities into the University's educational programs. If you have a disability-related need for reasonable academic adjustments in this course, contact the Office for Disability Services (ODS) at 814-863-1807 <callto:814-863-1807>  (V/TTY). For further information regarding ODS, please visit the Office for Disability Services Web site (http://equity.psu.edu/ods/)

 

In order to receive consideration for course accommodations, you must contact ODS and provide documentation (see the documentation guidelines at http://equity.psu.edu/ods/guidelines/documentation-guidelines). If the documentation supports the need for academic adjustments, ODS will provide a letter identifying appropriate academic adjustments. Please share this letter and discuss the adjustments with your instructor as early in the course as possible. You must contact ODS and request academic adjustment letters at the beginning of each semester.

 

Grading:

Final grades will be determined based on performance in the entire course as described below.

Midterm exam (20%): A 50 minute-long in-class open-book/note exam. They test your understanding of the materials covered in both lectures and paper discussions. The format of the questions is a combination of multiple-choices and essay questions. 

Final Exam (40%): A 90 minute-long exam that is similar to (but longer than) the mid-term exam in style. It is a comprehensive test of the knowledge learned during the entire semester. 

Quizzes (15%): THREE short quizzes to test your understanding of the material and to familiarize you with the exam format. The lowest score will be dropped. 

Student Presentation (20%): Each Friday, two groups of two students will present a developmental genetics-related article (or part of an article) to the class. The assignment will be posted on ANGEL no later than 12pm the preceding Monday. Students are expected to prepare their presentations in MS Powerpoint, revise them if needed and submit them to the instructor through email within 24 hours after the presentation (i.e. by 10am Saturday morning). Grading is based on your understanding of the material, clarity of presentation, ability to answer questions from the audience and the quality of the uploaded final version of the presentation. 

Participation (5%):  Attend lectures and participate in class discussions. Absence with legitimate reasons (illness, family emergency, business travel, etc) needs to be reported within 7 days in order to avoid grade deduction and schedule a make-up exam if needed. 

 

Biol 432 Fall 2013 schedule

M W F 9:05-9:55am

213 Buckhout Lab

(This schedule is tentative. It is subject to change according to the need of the class)

 

Day

Date

Topics

1

Monday

August 26

Introduction

2

Wednesday

August 28

Development overview

3

Friday

August 30

Genetic model system 1: worm

 

Monday

September 2

No lecture

4

Wednesday

September 4

Genetic model system 2: Drosophila 1

 

Friday

September 6

Discussion 1, 2

Jeffrey Addy/Khalil Al-Bachahjazi

Christian Bamberger/Sydney Blair

5

Monday

September 9

Genetic model system 3: Drosophila 2

6

Wednesday

September 11

Genetic model system 4: fish

 

Friday

September 13

Discussion 3, Quiz #1

Eric Bull/Geovanny Caicedo Montoya

7

Monday

September 16

Genetic model system 5: mouse

8

Wednesday

September 18

Genetics Basics

 

Friday

September 20

Discussion 4

Francis Dolan/Brian Ennis

9

Monday

September 23

Chemical mutagenesis 1

10

Wednesday

September 25

Chemical mutagenesis 2

 

Friday

September 27

Discussion 5, Quiz #2

Nicole Flynn/Gregory Gable

11

Monday

September 30

Chemical mutagenesis 3

12

Wednesday

October 2

Insertional mutagenesis 1: Transgenesis and gene trap

 

Friday

October 4

Discussion 6, 7

Preston Gall/Angelina Gaspero

Mahlon Kile/Lacy Heberlig

13

Monday

October 7

Insertional mutagenesis 2: Transposon

14

Wednesday

October 9

Gene-targeting 1

 

Friday

October 11

Discussion 8, 9

Rebekah Hoffner/Emily Johnston

Chelsea Jones/Gina Kang

15

Monday

October 14

Gene-targeting 2

16

Wednesday

October 16

Review session 1

 

Friday

October 18

mid-term exam

17

Monday

October 21

Gene-targeting 3

18

Wednesday

October 23

Tissue specific mutagenesis

 

Friday

October 25

Discussion 10, 11

Victoria Katchur/Andrew Kerner

Lindsey Mccracken / Kahla Lutz

19

Monday

October 28

Induction

20

Wednesday

October 30

Hh signaling and Hh Receptors

 

Friday

November 1

Discussion 12, 13

Andrew Mergel / Catherine Lefkowitz

Courtney Minetti/Jett Peng

21

Monday

November 4

Morphogen 1: bicoid and hunchback

22

Wednesday

November 6

Morphogen 2: Shh as a morphogen

 

Friday

November 8

 Discussion 14, Quiz 3

Jamie Purdum/Christian Radick

23

Monday

November 11

Morphogen 3: Chimera analysis

24

Wednesday

November 13

Temporal vs spatial gradient 1

 

Friday

November 15

Discussion 15, 16

Rebecca Rickard/Carolyn Rogers

Sherry Sabbah/Dylan Seebold

 

25

Monday

November 18

Temporal vs spatial gradient 2

26

Wednesday

November 20

Transcriptional Control

 

Friday

November 22

Discussion 17, 18

Ryan Shenigo/Robert Sulski

John Solloway/Jonathan Vicenty Gonzalez

27

Monday

December 2

Epigenetics

28

Wednesday

December 4

Animal cloning and Embryonic stem cells 1

 

Friday

December 6

Discussion 19, 20

Bandrea Weber/Benjamin Yi

Aaron Smith/ Samantha Flatley

29

Monday

December 9

Animal cloning and Embryonic stem cells 2

30

Wednesday

December 11

iPS cells and transdifferentiation

 

Friday

December 13

Review session 2

 

TBA

TBA

Final Exam